Cellgevity Supplementation Improves Left Ventricular Pump Performance and Mechanical Energy Conversion Efficiency in Healthy Humans

Abstract

Background: Chemical energy in glucose is metabolized to electrical and biomechanical works done in the heart. Cellgevity (CGV) is an antioxidant supplement that improves energy recovery in myocardial tissues.

Aim: The study evaluated the changes in left ventricular pump performance and mechanical energy conversion efficiency by applying the biomechanical concepts of changes in pressure, volume, time, and oxygen consumption in healthy subjects before and after eight- (8) week CGV supplementation.

Methods: Arterial blood pressure, electrocardiogram and echocardiogram parameters were measured in twenty-four (24) age- and sex-matched subjects before and after 8-week oral (2320 mg/d) CGV supplementation. Left ventricular pump performance and mechanical energy conversion parameters were then determined before and after CGV supplementation.

Results: After 8-week CGV supplementation in the healthy subjects, there was increase in left ventricular compliance (LVC) and its consequent left ventricular stroke volume (LVSV) which translated to increases in left ventricular ejection fraction (LVEF), cardiac output (CO), cardiac index (CI) and stroke volume-energy ratio (SVER) (p<0.05p<0.05 or p<0.001p<0.001). The reduction in rate-pressure product (RPP) translated to reduction in myocardial oxygen consumption (MVO22​) (p<0.01p<0.01, p<0.001p<0.001). The decrease in left ventricular work done in diastole (LVWDD​) and the increase in left ventricular total work done (LVWTT​) produced the increase in left ventricular mechanical work advantage (LVMWA) (p<0.001p<0.001). The increase in LVWTT​ translated to the increase left ventricular power (LVP) and produced an increase in left ventricular mechanical efficiency (LVME) in spite of the increase in left ventricular total energy (LVTE) consumed (p<0.001p<0.001). The decrease in MVO22​ produced the decrease in left ventricular mechanical efficiency index (LVMEI) (p<0.01p<0.01, p<0.05p<0.05). The decreases in MVO22​ and QRS duration with the increases in R-wave voltage, electrical diastole (ED) and RR interval were in corroboration with increases in CO, LVMWA and LVME in the subjects after CGV supplementation (p<0.05p<0.05, p<0.01p<0.01 or p<0.001p<0.001).

Conclusion: Study shows that CO, LVMWA, LVME, and LVMEI improved after CGV supplementation in healthy subjects. Thus, CGV supplementation may enhance left ventricular pump performance and mechanical energy conversion efficiency in healthy humans.